THE FIRST OMEN is the story of a woman in danger. In 1971, Margaret Daino (Nell Tiger Free) from the USA arrives in Rome to take her vows. She is warmly greeted by Cardinal Lawrence (Bill Nighy) at the airport and she is taken to Vizzardeli Orphanage, which is run by Sister Silvia (Sônia Braga). This is a time when civil rights protests are going on in the city and she is asked to be extra careful. Her roommate is Luz (Maria Caballero), who’s also all set to turn into a Nun. At the orphanage, Margaret gets friendly with a young, shy artist Carlita Skianna (Nicole Sorace). Margaret is distraught to see Carlita being mistreated by the other nuns and often locked in the ‘bad room’ because of her alleged misbehaviour. She relates to Carlita as she was considered a problem child at the orphanage, where she grew up. One day, she meets Father Brennan (Ralph Ineson), who warns her that things are not fine at Vizzardeli and that she must stay away from Carlita. Margaret doesn’t believe her but when Sister Anjelica (Ishtar Currie-Wilson) suddenly kills herself brutally, Margaret fears the worst. She once again meets Father Brennan who informs her about a sinister plan of a section of the senior members of the Church. Margaret’s world comes crashing down. What happens next forms the rest of the film.